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Anti-dsDNA is intended for the in-vitro measurement of specific IgG autoantibodies against double stranded deoxyribonucleic acid (dsDNA) present in human serum, as an aid in the diagnosis of systemic lupus erythematosus (SLE), in conjuction with other clinical findings. Autoantibodies to DNA recognise either single stranded (ss) or double stranded (ds)forms of DNA. Anti-ssDNA autoantibodies are not disease specific, being associated with a range of autoimmune conditions including; drug induced systemic lupus erythematosus, mixed connective tissue disease, rheumatoid arthritis, scleroderma and Sjogren's syndrome. In contrast, anti-dsDNA autoantibodies are associated more specifically with SLE, where immune complex formation is thought to play a major role in the pathogenesis of the disease. The deposition of immune complexes leads to inflamation and the renal and vascular characteristics of the disease. Sudden increases in SLE disease activity are generally preceded by a rise in anti-dsDNA levels, followed by a steep drop at the height of the disease. This observation confirms the necessity of monitoring the level of anti-dsDNA autoantibodies in SLE patients on a regular basis. Laboratory Testing
Please contact our lab for further information Antiphospholipid antibodies, including anti-cardiolipin antibodies, are frequently detected in sera from patients with systematic lupus erythematosus. Numerous reports have associated these autoantibodies with various venous and arterial thrombotic disorders, including cerebral infarction, deep venous thrombosis, thrombocytopenia, plumonary embolism and recurrent fetal loss with placental infarction. In SLE and SLE-like conditions, antiphospholipids are thought to occur in between 18-61% of the patients. In the general population, the prevalence is 0-14%. So, the presence of antiphospolipids would give weight to an existing diagnosis, or certainly point toward SLE as a consideration. Laboratory Testing
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